Sentence examples for involvement of the endogenous from inspiring English sources

In sum, the present study did not support a direct involvement of the endogenous opioid system in the attenuated pain sensitivity observed in individuals at increased risk for hypertension.

The involvement of the endogenous secretory receptor for AGEs (esRAGE) in VFs in those with type 2 diabetes, however, is still unknown.

An involvement of the endogenous opioid system after cocaine use was shown in subjects with current cocaine abuse/dependence (Zubieta et al., 1996; Gorelick et al., 2005).

3 However, information is still lacking regarding the involvement of the endogenous μ-opioid receptor (μOR) system in the allodynic response during migraine attack, which could provide a molecular explanation of why certain patients have increased cutaneous sensitivity.

The involvement of the endogenous ERbeta system in the mechanism of action of 3beta-Adiol in these cells is supported by the ability of the compound to activate ERE-mediated transcription, an effect that is dose-dependently counteracted by the presence of the pure antiestrogen ICI 182,780.

While we can only speculate on potential biological mechanism underlying these associations, we like to emphasize the notion of an involvement of the endogenous opiod system, given that both pain and SI are associated with altered function of this regulatory system.

Next, in an effort to evaluate the involvement of the interaction between endogenous Kv2.1 and syntaxin in the Ca2+-regulated secretion from PC12 cells, we aimed to disrupt this interaction and to assay the impact on secretion.

This simple but convincing experiment was the basis for suspecting the involvement of endogenous IGFBPs in the loss of IGF-1 effects in OA chondrocytes, and it was a prerequisite to justify their targeting.

Release was triggered also in the absence of synaptotbrevin 2, suggesting the involvement of an endogenous tetanus toxin-insensitive synaptobrevin.

In neurobiological research focused on the relation between neuroendocrine and behavioral parameters, it is a challenge to reveal the functional involvement of endogenous neuropeptides of the brain.

To further demonstrate the involvement of endogenous dopamine in the suppression of octopamine signaling, we used the Sephadex beads.