Sentence examples for involvement of death from inspiring English sources

Although the precise mechanisms of bystander killing remain elusive, we have previously reported the involvement of death ligands, which was later supported by other studies.

When treated with reagents that induced ER stress or proteaosome inhibition, the cells could activate the apoptosis system directly through caspase-8, without the involvement of death receptor signaling.

The early detection of caspase-8 activation suggested the involvement of death receptors, known to trigger apoptosis through the engagement of this protease, with downstream activation of caspase-9, subsequent to cytochrome c release to the cytoplasm.

Our data unveils, for the first time, the involvement of death receptors on the oligomeric A β-induced apoptosis in brain vascular cells pinpointing to DR4 and DR5 as major players in CAA-related dysfunction.

Based on our data illustrated in Figure 1, indicating that A β-induced apoptosis involved initial activation of caspase-8 with decrease of c-FLIP, suggestive of primary involvement of death receptors engaging the adaptor molecule FADD, we focused our attention on the upregulation of the TRAIL receptors DR4 and DR5, known to be expressed in EC and throughout the brain.

These results strongly suggested an involvement of the death receptor pathways in the delayed cell death of the irradiated cells.

To exclude possible involvement of cell death induced by QD-PEG-NH2, we therefore surveyed apoptosis and necrosis with FACS analysis after PI and FITC-conjugated Annexin V staining.

The GO analysis pointed out the possible involvement of the death receptor mediated activation of apoptosis in the XpdTTD liver.

However, we cannot exclude the involvement of other death receptors.

Most studies showed the involvement of the death receptor pathway.

Recent findings make the involvement of the death receptor pathway questionable though [ 24, 25].