Transcription factor E2F is primarily considered to regulate the G1/S transition of the cell cycle but its involvement in the regulation of mitosis has also been recently suggested.
But with Japan leading the opposition to any United Nations involvement in the regulation of marine species, and China, the largest consumer of shark fins, strongly opposed, the prospects of a deal appear remote.
HCRTR2 in particular has received a lot of attention due to its involvement in the regulation of sleep and pain, functions highly relevant in the CH pathophysiology [5].
However, CGRP and its receptor are also expressed in the anterior pituitary, suggesting a possible involvement in the regulation of hypothalamo-pituitary tract functions [79].
In addition, hypothalamic inflammation was also shown involvement in the regulation of hepatic steatosis in physiological and pathophysiological conditions (Milanski et al., 2012; Valdearcos et al., 2015).
As our knowledge of IL-12 family members is rapidly growing, it will be important to specify their involvement in the regulation of mycobacterial infection.
REM-sleep is affected in CH which is in line with our current understanding of CH and newer studies indicating hypothalamic involvement in the regulation of this sleep stage.
Given the relatively recent discovery of miRNAs and their potential involvement in the regulation of almost all cellular processes, we examined whether miRNAs that are differentially expressed in CF airway epithelium control expression of ATF6.
The functional linking of orexins with leptin and insulin suggests the possibility of its involvement in the regulation of the adipoinsular axis, and the present investigation was designed to examine the potential role of orexins in this axis regulation.
The interest in the sialic acids chemistry has rapidly increased in last years, especially since their involvement in the regulation of a great variety of biological phenomena was recognised.
These well-established epigenetic mechanisms, including DNA methylation, histone modifications, and miRNAs, are essential for normal development and are now intimately linked to disease phenotypes through their involvement in the regulation of gene transcription.
