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In the older definition ALS is considered as a disease exclusively characterized by preferential loss of motor neurons in the motor cortex, brainstem, and spinal cord, that is, by a pathological involvement exclusively of the motor system.
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In all studied patients involvement of the legs was present (100%), involving exclusively the legs in 10 (55%), legs more than arms in 6 (33%) and also the face in two of these 6 (11%).
Theoretically, equal depression of the AMPA and NMDA components would indicate involvement of exclusively presynaptic mechanisms, whereas differences in depression would also indicate involvement of postsynaptic mechanisms.
A specific muscle involvement, not exclusively related to the nerve involvement, was observed in all the patients who underwent a muscle biopsy.
Despite a low SN detection and a high false negative rate, our results underline the contribution of ultrastaging, using combined serial sectioning and IHC to detect micrometastases; 20% of our patients with lymph node involvement were exclusively diagnosed as a result of ultrastaging.
Of course, there are obvious ethical quandaries in confidently assuring patients of privacy when their research involvement occurs almost exclusively in a public setting like the internet.
This finding suggests that M1 involvement is not exclusively linked with the use of the internal strategy but rather directly with the process of mental rotation.
PTB (N = 111) had involvement of lung parenchyma exclusively.
Shihan et al. have shown that the involvement of the CRM exclusively by a metastatic lymph node is rare.
To facilitate readers' interaction and involvement, a Facebook page exclusively dedicated to the Textbook was set up in January 2014.
Therefore, patients with exclusively intrathoracic involvement (i.e., confined to lung parenchyma, pleura, and intrathoracic lymph nodes) were considered as PTB for the purpose of this analysis.
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CEO of Professional Science Editing for Scientists @ prosciediting.com