Sir Malcolm Bruce, the party's deputy leader, said Kingston and Portsmouth involved "very difficult local circumstances".
Due to the complexity of reactions in AOPs, the effect of different operational parameters involved are very difficult to determine, leading to uncertainties in the design and scale-up of chemical reactors of industrial interest.
"Her Ph.D. project involved plants very difficult to access...
However, the number of complex, interacting effects involved makes any complete understanding very difficult to achieve.
Clive Goodman was the royal reporter - you could understand why he might be interested in hacking into members of the royal household, which did occur, but not why other individuals were involved, and we found it very difficult to find out further information.
Since the distribution of the random variables involved in the model are very difficult to be theoretically retrieved, classical statistical methods for parameters estimation, like maximum likelihood, could not be applied to this case.
"The athletes and the players would not get the attention they deserve, and for all the other sponsors and broadcasters being involved it would be very, very difficult to manage.
The available models involve many parameters that are very difficult to estimate.
However, with semiparametric models (iii) and (iv), such an approach involves smoothed estimation and is very difficult to employ.
3. no motivation for treatment (actively or passively resisting treatment; the patient is very difficult to involve in any form of treatment, including treatment by the general practitioner).
