are the two most frequently involved variants [ 8].
Approximately half of these interactions involved variants in the solute-carrier genes (7 interactions) and TGFB3 gene (5 interactions).
Examples of sumoylation at variant sites have been reported, and while it is not known how Ubc9 recognizes such target sequences, it is speculated that the E3 component may be especially influential in modifications involving variant sites [12], [33].
We define the transcript diversity index (TDI) as the sum of splicing patterns involving variant exons (Classes II, III and IV), which is also (100 – Class I).
We have also defined the transcript diversity index (TDI), for quantifying complexity within the AS genes of any species, as the fraction of splicing patterns involving variant exons.
It is also possible that these genes may be implicated in disease susceptibility via regulatory mechanisms involving variants outside the chromosomal boundaries defined for each gene considered.
The data involve variants in the coding and flanking intron sequences of the human BRCA1 and BRCA2 genes in Hispanic subjects with breast cancer.
A second example involves variants in a gene desert at chromosome region 9p21 associated with coronary artery disease (McPherson et al. 2007).
Structural equation modeling provided sufficient discrimination to indicate that the association of a single nucleotide polymorphism with a lipid trait was mediated through a metabolite at 15 of the 38 sets, and involving variants at the FADS1 and GCKR loci.
From 1,505 env sequences obtained using a single genome amplification approach we show that 78% of infections involved single variant transmission and 22% involved multiple variant transmissions (median of 3).
