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However, bottom graphs show that there was no difference in time to EC opinion if the analysis is limited to EC that were involved both before and after MD-CTA (on different clinical trials), while a large difference was evident in the comparison including EC that were involved only before or only after MD-CTA.
However, we cannot draw definitive conclusions on the role played by the MD-CTA because we see shorter time to EC opinion after MD-CTA only in the more biased comparison that include EC involved only before or only after MD-CTA; therefore, it is reasonable that the observed difference is due to a selection bias of EC, rather than to the effect of MD-CTA.
Twenty-two EC received applications both before and after MD-CTA; 85 EC were involved only before (34) or only after (51) MD-CTA.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com