Sentence examples for involved more specific from inspiring English sources

The ACPA specificities were initially restricted and without any obvious epitope profile, but over time expanded with epitope spreading and involved more specific responses, especially with regard to antibody reactivities against α-enolase CEP-1/Eno5-21 CEP-1/Eno5-21 CEP-1/Eno5-21and fibrinogen(CCP-1/Fib307-324), when approaching the onset of symptoms [ 7, 8].

These ACPA antibody specificities were initially restricted and without any obvious epitope profile, but over time they expanded and involved more specific responses, especially antibodies against α-enolase CEP-1/Eno5-21 CEP-1/Eno5-21 CEP-1/Eno5-21and fibrinogen(CCP-1/Fib307-324), when approaching the onset of symptoms [ 5].

This hypothesis dictates identifying morally relevant respects in cases, which introduces a role for further hypotheses involving more specific principles that pick out those respects.

The second process would involve more specific mechanisms, with the recognition of less typical binding sites, possibly in cooperation with other DNA-binding factors.

Regulation of their expression might exploit the pathways of peripheral light reception, but could also involve more specific mechanisms linked with dedicated photoreceptor function.

Most likely, procollagen folding in ER involves more specific action of some chaperone molecules, which increase the triple helix stability by preferential binding to it.

Over time antibody positivity expands, involving more specific responses when approaching the onset of symptoms.

After completing this exploratory analysis, future work may involve more specific questions targeted at a limited subset of products, in order to make better comparisons.

Studies based on biomarkers of exposure and adverse effects may be helpful but should involve more specific molecules than biomarkers used in previous studies.

Enteric fermentation studies suggest that the influence of lignin on microbial deconstruction of plant cell walls may be primarily due to physical mechanisms such as shielding of cellulose but the effect of lignin may also involve more specific molecular interactions [ 25, 26].

In a similar vein, the "new situations and activities" as referred to in items of the BIQ unfamiliar situations subscale also involve more specific novel experiences as described in the BIQ preschool/separation (i.e., adjustment to new situations) and physical challenge (i.e., exploration of new play equipment) subscales.