As the regulatory proteolysis of a certain substrate protein is known to rely on E3 ligases that exhibit pronounced substrate specificity and operate in a precisely defined spatio-temporal manner as for example demonstrated for Aurora kinases38, our data strongly suggest that UFD-2 and CHN-1 are not involved in the developmental regulation of UNC-45.
DNA methylation is a key epigenetic mechanism involved in the developmental regulation of gene expression.
Ultimately, detailed mechanistic studies for let-7 biogenesis and its regulation involved in the developmental timing, cell division and differentiation in animals should be elucidated.
Although some of the genes that showed significant changes in expression may also be involved in the developmental stage, there is no doubt that most of the responsive genes were expressed due to Pi stress as shown by the statistical confirmation of the differences in gene expression over time during −P and ++P treatments.
Soo was involved in the developmental process of the musical, according to Aaron Harnick, a producer of the show.
MED12 is also a critical coactivator for the gene SOX9, which is involved in the developmental regulation of neurons, cartilage and bone.
These findings suggest that, in adult animals, toxic doses of METH can differentially influence the expression of transcription factors involved in the developmental regulation of dopamine neurons.
Both SHH and TP53 were included in one of the sub-clusters directly involved in the developmental process of embryonic cell lines.
To further understand the molecular mechanism of maturation, other gene regulations involved in the developmental process also need to be examined in M. nipponense.
Analysis of genes related to "nervous system development and function" (Fig. S1, Table 2) revealed 5 sub-functional clusters involved in the developmental processes.
Altogether these expression patterns identify additional key genes involved in the developmental and signaling pathways that were revealed by increasing the number of experiments and comparing the status of transcription before and after IR in WT and mutants.
