Class I antigens restrict cytotoxic T-cell (CD8+) function thus killing viral infected targets, while class II antigens are involved in presentation of exogenous antigens to T-helper cells (CD4+) by antigen presenting cells (APC).
The DC subpopulation/s that are involved in presentation of tumor antigen in B16.OVA melanoma tumors have not been precisely identified, however, in other tumor models multiple DC subpopulations can present tumor antigen in the draining LN [45].
In this way we not only take into account MHC II, commonly involved in presentation of exogenous antigens, but also MHC I, involved in cross-presentation [ 20, 21].
HLA-DR and other MHC molecules are involved in presentation of antigens to T cells, and in positive and negative selection of T cells in the thymus.
This result corresponds with the data that endotoxin has been demonstrated to bind to HDL in the presence of sCD14 and LPS binding protein (39, 40), an enzyme involved in presentation of endotoxin to sCD14.
Because CS/DS-GAG expression and function depends on the composition of PGs expressed, studying the nature of the PG(s) involved in presentation of P-selectin-reactive CS/DS is important.
Heat shock proteins (HSPs) involved in antigen presentation and cross-presentation play important roles in activation of immune-related cells such as macrophages, lymphocytes, and DCs [ 7– 9].
So far, the armory has mostly played host to outside producers, especially the Lincoln Center Festival, although it is heavily involved in all presentations given its unusual nature.
HLA-B protein known to be present on surface of nucleated cells is involved in antigen presentation to cytotoxic T cells.
