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Class I antigens restrict cytotoxic T-cell (CD8+) function thus killing viral infected targets, while class II antigens are involved in presentation of exogenous antigens to T-helper cells (CD4+) by antigen presenting cells (APC).
The DC subpopulation/s that are involved in presentation of tumor antigen in B16.OVA melanoma tumors have not been precisely identified, however, in other tumor models multiple DC subpopulations can present tumor antigen in the draining LN [45].
HLA-DR and other MHC molecules are involved in presentation of antigens to T cells, and in positive and negative selection of T cells in the thymus.
In this way we not only take into account MHC II, commonly involved in presentation of exogenous antigens, but also MHC I, involved in cross-presentation [ 20, 21].
This result corresponds with the data that endotoxin has been demonstrated to bind to HDL in the presence of sCD14 and LPS binding protein (39, 40), an enzyme involved in presentation of endotoxin to sCD14.
Because CS/DS-GAG expression and function depends on the composition of PGs expressed, studying the nature of the PG(s) involved in presentation of P-selectin-reactive CS/DS is important.
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The pension funds' adviser, Pacific Corporate Group, is still evaluating the wisdom of investing in Knickerbocker, and they said the Giuliani administration has been involved in presentations concerning the fund since last fall.
Heat shock proteins (HSPs) involved in antigen presentation and cross-presentation play important roles in activation of immune-related cells such as macrophages, lymphocytes, and DCs [ 7– 9].
HLA-B protein known to be present on surface of nucleated cells is involved in antigen presentation to cytotoxic T cells.
Close examination of the antigen presentation pathway in the disease tissue identified elevated transcriptional expression of multiple components of the H2 locus involved in antigen presentation to both CD8+ and CD4+ T cells.
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