This prompted us to investigate if loss of function could be involved in the length and severity of disease progression.
The higher abundance of pan-twinfilin staining in shorter stereocilia rows versus the longest row indicated the possibility of twinfilin being involved in stereocilia length regulation.
Many of these proteins are actively involved in telomere length regulation, telomere DNA replication, telomere capping, and formation and/or resolution of t-loop and aberrant telomere structure.
Tel1 is the yeast homolog of the human ataxia telangiectasia (ATM) checkpoint protein, primarily involved in telomere length regulation [37], [38].
This is likely to be largely due to the complexity of physiology involved in determining length of life, but may be also in part due to technical issues in experimental design hampering a clear path of progress [11].
Rap1 interacting factor 1 (Rif1), was identified as a protein involved in telomere length regulation in yeast.
In summary, the screening of yeast deletion collections has identified many novel genes involved in telomere length regulation.
Cdc13 is also involved in telomere length regulation by recruiting or preventing access of telomerase to the telomeric overhang.
Likewise, Tang et al. (2007, 2010) found two juxtaposed regions involved in ear length and plant height but without overlap.
In a recent turn of events, another nuclear function has been proposed for the Whirlies as AtWhy1 was shown to be involved in telomere length homeostasis [ 9].
