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Somatic mutation and homozygous deletion of CDKN2C was detected in 2 5% anaplastic oligodendrogliomas, suggesting alteration of this gene is involved in progression of a subset of tumours (Husemann et al, 1999; Pohl et al, 1999; He et al, 2000).
A study from the Foundation for Advancement of International Science, also in Japan, showed that laughter seems to lower levels of a protein involved in the progression of diabetic nephropathy, a kidney disease that occurs as a result of diabetes and which is the leading cause of kidney failure.
In addition, ROR1 is critically involved in progression of a number of blood and solid malignancies.
IL-2 is a cytokine involved in the progression of T lymphocytes as a growth factor [ 35].
Recently, miR-15b has been declared to be involved in progression of an element of cancer tissues.
Control specimens (n=31) were obtained from the Department of Rheumatology RUMC and were all involved in a study of osteoarthritis progression.
These data corroborate our in vitro findings that HB-EGF is involved in the progression of a variety of carcinomas.
We hypothesize genetic and environmental factors involved in the progression of a particular complex phenotype are participants in the same underlying cellular processes.
Most of the known genetic mechanisms involved in the progression of a tumor to the metastatic state involve the loss of function of genes that prevent cells from becoming invasive.
They proposed that S100A2 could potentially be a key protein involved in the progression of cholangiocarcinoma and may pose as a biomarker as well as a novel therapeutic target for this type of cancer.
A 20 amino acid mini-peptide derived from residues 73 92 of αB-crystallin protects human retinal pigment epithelial (RPE) cells from oxidative stress, a process involved in the progression of age-related macular degeneration (AMD).
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