The problems are characterized by the extent of the environmental system involved, dynamic and interdependent nature of stressors and their impacts, diversity of stakeholders, and integration of social, economic, and environmental considerations.
The underlying pathogenesis involves three predominant and interdependent biologic processes: inflammation, epidermal hyperproliferation, and altered differentiation with parakeratosis.
Implementing clinical practice guidelines (CPGs) in healthcare settings is a complex intervention involving both independent and interdependent components.
Although these two concepts may appear by definition to be opposed to each other, in practice professional work involves both independent and interdependent elements [ 19].
Hospital discharge takes place on a day-to-day basis, and involves complex, interdependent functions that require interaction and coordination among a multidisciplinary team of stakeholders, i.e., doctors, nurses, receiving health-care providers, patients, next of kin, and patient coordinators.
Since PDT involves three interdependent and dynamic treatment factors (i.e. light, photosensitiser and oxygen), complete and accurate dosimetry is a difficult problem and is the focus of ongoing research by several groups.
It was proposed that p53-NTD can be involved in interdependent interaction with the C-terminus to regulate defined function of p53 [33].
Other rules in the tree are more complicated and involve multiple interdependent attributes.
Additionally, noncancer end points are likely to be complex and involve multiple interdependent physiologic changes.
It also seems, as a more general factor to consider, that almost all organisms are involved in complex interdependent relationships as part of a "metaorganism" [ 26, 27]; we therefore assessed differentially expressed sequences without the limitation of direct mapping or annotation to Salix purpurea genome alone, providing the opportunity for an unconstrained view of the origin of sequenced RNA.
