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The antinociceptive activity of MEMC involved activation of the non-selective opioid (particularly the μ-, δ- and κ-opioid) and non-opioid (particularly adenosinergic, α2-noradrenergic, and β-adrenergic) receptors, modulation of the ATP-sensitive K+ channel, and inhibition of bradikinin and protein kinase C actions.
Thus, the cell apoptosis induced by SSd and radiation may involved activation of the p53/Bcl2 pathway.
The accelerated death of lymphocytes in current study might serve to certify the speculation that AFP-mediated apoptosis involved activation of the effector caspase-3-like proteases [ 9].
Mechanistic studies suggest that the effect of lithium mainly involved activation of the transcription factor NF-AT and specific induction of a subset of proliferation-related genes.
We assessed whether the decreased production of lactate and increased respiratory rate induced by DCA treatment in MM cells involved activation of the PDH complex as measured by the dephosphorylation of PDH-E1 α.
The anti-apoptotic effect of CO involved activation of the p38 MAPK isoform, and inhibition of Fas and/or FasL expression and other apoptosis-related factors, including caspase-3, Bax proteins and mitochondrial cytochrome c release (Zhang et al., 2003).
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Exercise is followed by an intensity-dependent increase in sympathetic activity, which involves activation of the hypothalamus-pituitary axis.
One mechanism involves activation of the heterotrimeric AMP-activated protein kinase (AMPK), a cell-autonomous sensor to energetic changes regulated by ATP to AMP ratios.
The mechanism by which ANP inhibits ICaL involves activation of the pGC/cGMP pathway, and cGMP-stumulation of PDE2 activity, leading to inhibition of the cAMP/PKA pathway.
In this study, we have analysed the step involving activation of the TMD of the receptors.
This immune inflammation involves activation of the complement cascade via the classical pathway.
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