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A possible mechanism to explain this shift toward the non-amyloidogenic processing may involve the essential role of Tyr682 for normal endocytosis of APP as previously shown in vitro [11].
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Our FRET and CD results show that beta sheets involving the essential Aβ (14 23) fragment, strongly prefer the anti-parallel topology.
These findings strengthened the hypothesis that the phosphatase domain involves the essential regions required to exert protein phosphatase activity.
A particularly well-characterized example involves the essential translation release factor Sup35, which confers on cells a heritable nonsense suppression phenotype upon conversion to the prion form (Cox, 1965; Ter-Avanesyan et al., 1994; Patino et al., 1996; Paushkin et al., 1996).
These choices are of the utmost importance, because they involve the most basic and essential questions of human life what one is to be and do.
"It is essential to involve the youth in solving development problems because their genuine creativity and passion inspires new solutions from a different perspective.
To undertake this successfully, Arthur recognised that it was essential to involve the government in plans to create and develop an ophthalmic hospital infrastructure.
Many of the functional categories enriched among SP1 target genes (table 2) involve the most basic biological processes essential for cell survival.
These observations imply that these disease-related genes are more involved in the essential neural tissue functions than in the advanced brain activities.
Key enzymes involved in the essential metabolic and regulatory pathways are usually sought in the pursuit of potential drug targets.
Emotional design of multimedia instruction involves making the essential elements in the lesson's graphics more appealing, such as by rendering them with human-like features and with distinct, appealing colors (Um, Plass, Hayward, & Homer, 2012).
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