Sentence examples for involve substantial changes from inspiring English sources

The emerging plans are sensitive because a large number involve substantial changes to hospital services.

Some of the proposed security solutions involve substantial changes at the PHY layer of LTE networks which could be very challenging to implement on a commercial network and would require collaboration within the industry.

More common "natural experiments" involve substantial changes in traffic patterns.

Our recommendation, therefore, is that clinicians pursue a conservative approach that does not involve substantial changes in clinical practice.

This resource allocation strategy must therefore involve substantial changes in the expression of molecular transporter genes, and our transcriptomic analysis of C. ocellatus reveals upregulation of many such loci.

This is not a shortcoming of the simulation algorithm, as drawing from a state-dependent distribution does not involve substantial changes in the implementation, but rather an impracticality of the methodology, given the efforts needed to obtain multiple state-dependent delay distributions.

The zebrafish is known to undergo a larval to juvenile metamorphosis at this stage, involving substantial changes to the morphology of several organ systems, together with alterations to physiology and behaviour [48] (and references within).

The differentiation of a vegetative cell into a heterocyst involves substantial changes in cell morphology and physiology [ 5, 6].

Infection of plants by pathogens and the subsequent disease development involves substantial changes in the biochemistry and physiology of both partners.

This involves substantial changes in the average BSI value of the Iberian rodent faunas, supporting the prediction of a change in the pattern of ecological specialization in concert with the cooling pulse of the Plio-Pleistocene around 2.75 Ma.

Myogenesis is an ordered process whereby mononucleated muscle precursor cells (myoblasts) fuse into multinucleated myotubes that eventually differentiate into myofibres, involving substantial changes in gene expression and the organisation of structural components of the cells.