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Using combined immunofluorescence and telomere fluorescence in-situ hybridization, we show that the age-dependent increase of DNA damage involve predominantly non-telomere-associated γH2AX-foci, arguing against the hypothesis that telomere dysfunction in response to critical telomere shortening plays a primary role in producing senescence- and age-associated DNA damage in humans.
Cellular infiltration into the lamina propria and epithelium may involve predominantly neutrophils or lymphocytes, depending on the chronicity of the lesion [ 19].
Although heterologous CIA response is well known to involve predominantly a largely neutrophilic infiltrate, the success of PPI-2458 in ameliorating disease progression provides evidence of the crucial role of the vasculature in this model.
Nonsusceptibility to periodontal breakdown may involve predominantly Th1 which is involved in T-cell activation, cell mediated immunity, IFN- γ enhancement of innate immunity, and, if necessary, the production of protective antibodies [ 39].
We found that the simultaneous treatment of FASN+/HER2+ breast cancer cells with G28UCM plus trastuzumab or lapatinib (which involve predominantly HER2), resulted in a strong synergistic interaction, and that this was also observed with gefitinib or erlotinib (inhibitors of HER1 but also HER2 tyrosine kinase activities) [ 48, 49].
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Regarding alcohol-related aggression, about 12% of students have been involved, predominantly males (18%; females, 6%), but only 3.7% of adolescents reported involvement more than twice.
At a press conference, he said: 'Over the last four hours there have been sporadic but continuing outbreaks of disorder and violence involving predominantly young men.
Perhaps the most pronounced back-and-forth involves predominantly black and white palettes and those using brilliant hues — mostly red, yellow and blue.
But that study, like many others that look at the cost-effectiveness of bariatric surgery, involved predominantly female patients who were in their 40s or younger.
The metal-semiconductor field-effect transistor (MESFET) is a unipolar device, because its conduction process involves predominantly only one kind of carrier.
Grade No. 4-D A heavy distillate fuel, or a blend of distillate and residual oil, for low- and medium-speed diesel engines in non-automotive applications involving predominantly constant speed and load.
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