Sentence examples for involve methylation of from inspiring English sources

For instance, the CGG repeat diseases appear to involve methylation of the DNA containing the repeats, leading to gene silencing.

Both pathways involve methylation of arsenic via one-carbon metabolism with S-adenosyl methionine (SAM) as the methyl donor and requiring reduced glutathione (GSH).

The mechanism underlying the loss of expression appears to involve methylation of CpG sites within the promoter region and exon 1.

Epigenetic processes involve methylation of DNA and post-translational modification of nucleosomal histones, which contribute to a complex "epigenetic code" that superposes the nucleotide sequence to direct gene expression [ 4, 9– 11] (Fig.  1a).

A surprising result is that many observations have revealed that S100A4 is over-expressed in most other tumors [ 77- 82], yet in [ 76] the authors suggested that the mechanism of changes in the expression level of S100A4 may involve methylation of the S100A4 gene.

Although mutations in MMR genes are believed to account for most HNPCC, the mechanism responsible for the MSI-H phenotype in sporadic CRC seems to involve methylation of MMR gene sequences, resulting in downregulation of gene expression (transcription) and subsequently less functional protein (Kane et al, 1997; Cunningham et al, 1998; Herman et al, 1998; Kuismanen et al, 1999).

Silencing of genes has a complex mechanism, which involves methylation of DNA, histone modification and chromatin remodeling.

Accordingly, one of the accepted mechanisms for functional BRCA1 loss involves methylation of one BRCA1 allele combined with a loss of heterozygosity (LOH) event resulting in loss of the other BRCA1 allele21.

Therefore, in the final part of the study, we addressed whether Notch-1 promoter silencing by TNF also involved methylation of CpG dinucleotides.

Consequently, we cannot exclude that SAMe and betaine improve the response to pegIFNα/ribavirin treatments by mechanisms that differ from our proposed model of action that involves methylation of STAT1 as the key event.

In eukaryotes, epigenetic regulation via transcriptional silencing involves methylation of cytosine residues [ 85].