For the statistical analyses involving lung function measures as the dependent variables, pupils with missing FEV1 or FVC data were omitted.
The dissemination of mycobacteria from the lung to the draining LN (dLN) has been suggested to involve lung DC 36– 41, leading to the activation of antigen-specific T cells and the induction of effector function 42– 42.
Subjects involved in lung function and allergy tests, compared to those not involved, were more likely men, smokers, young/adults, exposed to passive smoking and with high education levels (data not shown).
A positively-charged helical C-terminus of SP-B may similarly be involved in lung function, as synthetic peptides representing the C-terminal domain adopt α-helical conformations [43], [44] and promote in vitro [43], [45] [47] and in vivo [46], [47] surfactant activities mimicking those of the native protein.
These results may indicate that IL-18 is involved in lung function alteration indirectly, perhaps via influencing from Th1 and Th2 cell responses or other integrated mechanisms [ 41, 44].
The clinical assessment of COPD often involves measurement of lung function parameters (e.g., FEV1) and exacerbation level of a patient to evaluate the disease progress and the therapeutic effect [ 3].
Asthma management programs for pregnant women which involve regular monitoring of lung function and assessment of asthma symptoms appear to be effective in reducing asthma exacerbations [ 11, 12].
This finding is of clinical relevance, as ASM cell remodelling is likely to be involved in the decreased lung function associated with the disease, but remains insensitive to the usual asthma therapies [33].
The latter results suggest that Robo1 may be involved in maintaining proper lung function and it may become essential when lung epithelium is destroyed during an influenza infection.
Among girls, although a similar pattern was observed and thus a marked reduction in the coefficients was seen, the association with SES remained statistically significant even in the model with 11 different predictors, suggesting a more complex impact of SES on lung function involving body size, composition, and other factors.
