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Adaptations to a new environment, such as a polluted one, often involve large modifications of the existing phenotypes.
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Adaptation to a new environment, such as a polluted one, often involves large modifications of the previous phenotype(s) and changes in gene expression and regulation during critical developmental stages may explain these phenotypic changes.
This can involve large sums of money.
The better-known cases involve large companies.
This mutation, identified in a patient with an LGMD phenotype, interfered with post-translational modifications involving LARGE (30).
Including them involves large uncertainties.
Coastal and offshore development which often involves large-scale dredging, infilling, coastal modifications, and the creation of artificial waterways has left the coral reef ecosystem in waters off Dubai, Abu Dhabi, Saudi Arabia and Bahrain severely damaged.
"But this lie involves larger issues.
If any of the proteins in question would be involved in the post LARGE modification, mutations should not result in loss of ligand binding as the basic ligand binding LARGE glycan scaffold would still be preserved and present.
Consistently the proteomic analysis shed light on large modification of enzymes involved in the transport and catabolism of metabolites necessary for energy production.
But the operative word is 'might'". A potential process could involve modifications to an existing large reptile - for instance, a Komodo dragon.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com