Sentence examples for involve attenuation of from inspiring English sources

Accordingly, scaling up alcohol interventions would require large infrastructure investments, and likely would involve attenuation of intervention fidelity and effect size.

Previous results have shown that Wnt supports pluripotency of ES cells (Yi et al., 2011) and that the switch to a NSC fate appears to involve attenuation of Wnt signaling (Aubert et al., 2002).

Otherwise, as the mechanisms of the cardiac depressant effects of these induction agents is likely to involve attenuation of trans-sarcolemmal Ca2+ flux [ 6], the dysfunction of sarcoplasmic reticulum Ca2+ handling or altered calcium transient properties described in septic hearts might be attributable to these differing results [ 24, 25].

Interestingly, Hoffman et al reported that BMP4 action in skeletogenesis involved attenuation of retinoid signaling [49].

None of the currently available JAK inhibitors are specific to mutant JAK2; their mechanism of action involves attenuation of JAK-STAT signaling with downregulation of proinflammatory cytokines, rather than selective suppression of the disease clone.

Our results demonstrate that adaptation to hypoxia involves attenuation of MBP-1 trandlossof and loss of MBP-1-mediated regulation of c-myc transcription, evidenced by decreased MBP-1 binding to the c-myc P2 promoter.

Our data further suggest that the beneficial effect of APS in acne patients involves attenuation of NF-κB signaling but not reduction of IL-6 or IL-8 secretion.

Thus, the present data that show that the investigated gero-preventive drugs suppress both, the mTOR/RP-S6 signaling and CDDS, would be consistent with the mechanism that involves attenuation of DNA replication stress.

In agreement with this, miR-146a, which is abundantly expressed in the heart (van de Vrie et al., 2011), protects the myocardium from ischemia-reperfusion injury in a process that involves attenuation of NF-κB activation (Wang et al., 2013).

A study with Lactobacillus casei Shirota showed that the probiotic induced a protective effect in a mouse model for fructose-induced liver steatosis, with possible mechanisms of activity involving attenuation of the Toll-like receptor (TLR -4 signalling cascade in TLR -4ver.

The psychological effect of having or receiving more than one deserves may be guilt or repression, but it seems inevitably to involve an attenuation of one's sense of self.