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Psychosis, schizophrenia and other serious mental illnesses involve a disruption in typical brain functioning, which translates into a very specific set of what can be considered disturbing behaviors.
Studies have found, for example, that bulimic subjects produce abnormally low amounts a hormone called cholecystokinine, or CCK, released by cells in the wall of the small intestine when food is present, indicating that the disorder may involve a disruption in the physiological signals that normally tell people when they have eaten enough.
All cancers involve a disruption of normal restraints in cell proliferation, differentiation, and survival.
The reasons are yet unknown, and may involve a disruption at some step of the circadian pathway that controls the nocturnal surge in melatonin secretion [32].
IM-associated edema is believed to involve a disruption of PDGF signaling.
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Clinical depression involves a disruption in brain chemicals that can occur with or without a precipitating event.
That left unanswered questions about whether the suspects' "evil intentions" involved a disruption of South Africa's elections -- something experts regarded as unlikely, given that officials had explicitly ruled out any such threat -- and why the suspects were expelled or extradited instead of being jailed and charged with crimes in South Africa.
A pathway that may contribute to metal ion induced carcinogenesis is by hypoxia signaling, which involves a disruption of cellular iron homeostasis by competition with iron transporters or iron-regulated enzymes.
This mechanism results in a complete self-destruction, involving a disruption of the cell membrane and a disassembly of all parts of the cell.
The shift may be ultimately desirable, but it is none the less difficult and involves a disruption of being.
Meanwhile, some researchers used tissue-specific gene expression data along with PPI networks to prioritize disease genes as many disorders are involved a disruption of the "molecular fabric" of different, healthy tissues [ 12].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com