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Of these, 13 823 people (men and women, 1 1) were drawn by individual randomisation from the population registry and invited directly to once only flexible sigmoidoscopy screening (one step invitation procedure); this process mimicked invitation procedures for national screening programmes.
The two former types could make use of a cascade invitation procedure to support involvement.
Yet, it might be feasible to use a modified invitation procedure for the total study group.
For detailed information regarding the randomisation and invitation procedure, we refer to the earlier publication (Van Rossum et al, 2008).
The revision of the UKCTOCS invitation procedure provides an example of the flexibility needed in running trials.
The screening program uses a centralized invitation procedure and all invitations will be sent out by the regional Comprehensive Cancer Centre Amsterdam.
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The practical organisation of the programme was based on centralised population sampling and invitation procedures.
Several changes were made, including setting the minimum age, increase of the token of appreciation, and changes in the invitation procedures, and the examination hours offered.
The invitation procedures of this study allowed for determining what percentage of patients participated in the SNS, given that they were willing to participate.
There are some differences between the ERSPC centres in, for example, the mode of recruitment, screening interval, invitation procedures and the PSA threshold leading to biopsy.
Data collection procedures for social networks of health professionals and patients were planned in the same period, with some extension for patients needed until July 2014 because of our invitation procedures (see p8 for details).
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