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One cause might be what investigators term a "controlled flight into terrain", or Cfit, where loss of instruments or irregular readings can make pilots lose their bearings and only become aware of danger too late if there is no visual reference – possible in the case of a descent through thick cloud.
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Undercover investigations have led to a $497 million judgment against the now defunct Hallmark Meat Packing company, and to the recent temporary shutdown of Central Valley Meat Company over what federal investigators termed "egregious, inhumane handling and treatment of livestock".
This analysis presents adverse experience terms as reported by the investigator; terms for ischemia-related events reported for these studies are found in Appendix II.
Treatment-emergent adverse events were translated from investigator terms to MedDRA terminology and summarised within and across dose levels for all patients who received at least one dose of ATN-161.
The bank has apparently cooperated fully with investigators in terms of providing documents and officials for interviews.
There is pressure exerted by healthcare institutions on investigators in terms of the productivity of scientific material.
To assess intra-observer and inter-observer reliability between the two investigators, the terms of semi-quantitative scoring were calculated by a weighted kappa statistic.
Some investigators have termed this a "glycation gap" and proposed that there are differences in the rate of glycation of hemoglobin ("low and high glycators") (39).
AEs were evaluated by investigators in terms of seriousness, maximum intensity (mild, moderate or severe), outcome and possible causality with study medication.
Prior to the now common community advisory boards in research in LMIC, the Majengo STD Program established linkages with the community through elected peer leaders, who engaged in dialogue and negotiations with investigators about terms and conditions for participation in the research.
Clinical adverse events were recorded throughout the study and evaluated by the investigator in terms of causal relation to study medication.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com