Functionally, using the investigator inputs, the simulation first establishes the stage II stopping rules (RR, TTP) required to achieve the desired power.
Investigators input data into the EmDOC Internet site at 10 00 p.m. on 7 random days each month.
The initial questionnaire was developed based on the prior experience of investigators, input from colleagues, peers as well as patients.
Results of Round 2, coupled with investigators input, resulted in the list of essential items presented in Figure 1, which will become part of the new instrument for critical appraisal of RCTs of NPs.
To make sure that the results are credible and accurate, two investigators input all information in the STATA software version 12.0 (Stata Corp ,College Station, TX, USA) separately and arrived at an agreement.
To make sure that the results are credible and accurate, two investigators inputted all information in the STATA software, Version 12.0 (StataCorp, College Station, TX, USA), separately and arrived at an agreement.
This study was designed, conducted, and written by NCI investigators with input from investigators at GlaxoSmithKline.
The resulting database is one that can be queried with a cheminformatic search engine into which an investigator can input a chemical structure and pull any related information of interest.
Second, the true median TTP of a simulated drug is established according to the investigator's input parameters and on whether true 'good' or true 'bad' drugs are being assessed.
