Three patients received 50.4 Gy in 28 fractions, rather than the protocol specified 50 Gy in 25 fractions, because of investigator prescription error.
Filled in questionnaires were checked daily for completeness and accuracy by the principal investigator, and errors were corrected before data entry on Epidata 3.1 (The EpiData Association, Odense, Denmark).
The lengthy investigation has been hampered by the mysterious deaths of witnesses, the unwillingness of Sikh immigrants to cooperate with investigators and errors by the Canadian police and intelligence agents, who inexplicably erased hours of wiretap tapes.
Double-masked, controlled trials, usually with placebos, are the accepted gold standard in investigating new drugs and treatments because they have proved to be the best way to minimize investigator bias and error and maximize similarities between study groups.
These include: (i) shortcomings in experimental design and execution that involve hypothesis conceptualization, statistical analysis, and data reporting; (ii) investigator bias and error; (iii) validation of reagents including cells and antibodies; and (iv) fraud.
16 The unusually high baseline PASI scores noted in five patients (range 50 72), if not correct, may have been due to investigator or recording error.
By Avi Zenilman February 18 , 2009Investigators think pilot error, not icing, may have caused the Buffalo crash.
Investigators think pilot error, not icing, may have caused the Buffalo crash.
Investigators said operator error or mechanical failure might be to blame, or a combination of both.
Investigators blamed human error; the pilot was at a control panel far from the plane.
