In our present study we sought to close this gap by addressing the expression of functionally glycosylated α-DG during T cell development and investigating the function of DG in developing and mature T cells in vivo.
In addition, she is investigating the function and regulation of small RNAs in metazoan.
At present, she is investigating the function and organization of connections between the amygdala and midbrain dopamine neurons.
Localized gene knockdown is a valuable tool for investigating the function of gene products in tissues.
His group is also investigating the function of progenitor cells during repair, and the translational use of fat-derived stem cells in chronic wound therapy and tissue engineering.
She is currently a postdoctoral fellow in the laboratory of Scott Hultgren, Washington University School of Medicine, where she is investigating the function of bacterial extracellular amyloid fibres called curli, and identifying strategies for the interference of their assembly.
Another major area of research in the lab centers on investigating the function of the Drosophila segmentation genes during neuronal development and understanding how these genes may have contributed to the evolution of neural complexity.
Ellen's research focuses on investigating the function of genes that are strongly associated with autism to determine how disruption of these genes alters brain development and the neural circuits underlying simple behaviors.
Therefore, the design of RNA molecules with specific structural properties has many potential applications, e.g. in the context of investigating the function of biological RNAs, of creating new ribozymes, or of designing artificial RNA nanostructures.
The use of experimental models of biomembranes for investigating the function of integral proteins, either incorporated in biomembrane fragments or proteoliposomes adsorbed on metal-supported mixed alkanethiol ∣ lipid bilayers, or directly incorporated in metal-supported lipid bilayers, is described.
These ligands, after confirmation of their activities, will provide tools for investigating the function of MATs as well as the potential for new therapeutic agents in mental health applications.
