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Schizosaccharomyces pombe is a model system for investigating pathways that eukaryotic cells use to sample morphological space [5].
The scope of this article is limited by the depth of the case studies presented, and the choice of the authors to reflect on the design of EWS through investigating pathways to involving local communities.
We previously demonstrated that NCCIT cells are a useful model system for investigating pathways involved in maintaining self-renewal [6].
The gene pathway database compiled in Kyoto Encyclopedia of Genes and Genomes (KEGG) has been a valuable source for investigating pathways.
While socioeconomic status is an important predictor of diabetes outcomes [ 16], additional social determinants such as psychosocial influences are important to consider when investigating pathways [ 17– 17].
We focused on investigating pathways that had not been examined in AGRP neurons, such as systems for ER-stress, circadian regulation, and synaptic function, as well as genes encoding ion channels, GPCRs, and secreted proteins.
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In addition to investigating pathway enrichment based on the KEGG database, we also subjected a set of 'custom' pathways to analysis by GSEA (Additional File 6).
Future research should investigate pathways of PCB contamination of the marine environment".
These results will allow us to investigate pathways relevant to dopaminergic cell death in further detail.
As the measured metabolites are scattered across the investigated pathways, local network properties (e.g., connectivity) may have a negligible discriminatory power.
Thus, it is important to also investigate pathways of nanoparticle uptake by functional, mechanistic methods also.
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