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Researchers are increasingly interested in using human biomonitoring – the measurement of chemicals, their metabolites or specific reaction products in biological specimens/body fluids – for investigating exposure to environmental chemicals.
Human studies investigating exposure to carbaryl and chlorpyrifos and associations with male reproductive health are limited.
Researchers investigating exposure and risk patterns in children and links to health outcomes may need repeated measurements to derive accurate findings.
We addressed this question by investigating exposure to diesel and gasoline emissions with respect to risk of colorectal cancer in men.
When we considered one covariate at a time with simple univariate logistic regression, we had 545 subjects for investigating exposure to PM10, 780 subjects for investigating exposure to NO2, and 829 subjects for all other covariates; see Table 1 for a list of all risk factors included in our analysis.
In a cross-sectional analysis investigating exposure on the previous day, CRAE narrowed by 0.4 µm (95% CI: –0.8, –0.04) in association with a 9-µg/m increase in PM2.5 (Adar et al. 2010).
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When investigating exposure-response relationships, there are several choices how to deal with exposure data.
Scientific research should clarify the relationships between environmental changes and their health impacts by documenting the relevant exposure pathways, their magnitudes, and by investigating exposure-dose response rexposure-dose response
The importance of mediation is well argued in Hafeman and Schwartz [ 9] where they demanded the opening of the 'black box' when investigating exposure-disease relationships.
We previously described methods for investigating exposure-risk relationships using individual participant data from multiple studies (3) and proposed measures of discrimination for the stratified Cox model (4).
A second study investigating exposures from the same accident measured the prevalence and duration of breastfeeding among 466 women exposed to PBB [ 7].
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