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Potential non-linear relation was investigated using restricted cubic splines.
A potential non-linear relation between fish consumption and RA risk was investigated using restricted cubic splines with three knots at fixed percentiles (10%, 50%, and 90%) of the exposure distribution.
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However, all of the investigated herds used restricted levels of protein in sow feed, and had previously tried minimizing protein content with no preventive effect.
Contributions of socio-demographic characteristics (gender, age, pubertal stage, SES) on the variability in ASQ scale scores and the summary score were investigated using Hierarchical Linear Models (HLM) with Restricted Maximum Likelihood Estimation [ 22], whereby 'city' was specified as subject grouping variable, and gender, age, pubertal stage and SES as fixed parameters.
Significant associations were investigated further using linear mixed effects regression models fitted using restricted maximum likelihood, adjusting for the effects of age and sex, and for heterogeneity between physician practices.
Restricted conformational transitions in oxyethylene chains have been investigated using a molecular mechanics approach.
In the final model, we investigated the linearity assumption of continuous variables by likelihood ratio tests of a model using restricted cubic splines for these variables against a model with the variable entering as linear.
The linear association between age and outcome was investigated for the Martingale residuals and found to be acceptable, but for the sensitivity analysis, age was also modelled using restricted cubic splines.
To date, the molecular genetic diversity of this plant has been investigated using only RAPD markers (Schnell et al., 1999; Offei et al., 2004) within a limited number of accessions and across restricted areas.
To investigate the impact of follow-up duration on the statistical analyses, multivariate logistic regression analyses were used to explore prognostic factors using restricted data until 1, 2, and 3 years of follow-up.
Model parameters were estimated using restricted maximum likelihood.
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