Sentence examples for investigate the functional implication from inspiring English sources

The purpose of the present study was to investigate the functional implication of Dp71 and the associated protein complex in the Müller cell-mediated maintenance of retinal integrity.

The initial observation that mHTT accumulates in striatal astrocytes, and the fact that ion channels have been implicated in neurodegenerative diseases earlier lead Tong et al. to investigate the functional implication of glial cells in the pathophysiology of HD.

To investigate the functional implication of the interaction between RILP and RalGDS, the effect of RILP on the RalGDS-mediated activation of RalA was assessed by GST-pulldown assay using GST-RalBP1 RBD), GST-RalBP1 RBDor GST-Sec5 RBDD) GST-Sec5 RBDhe amornt of the activated RalA-GST-Exo84 RBD GST-Exo84 RBD

To investigate the functional implication of the GWAS-detected RNASET2 risk factor in vitiligo pathogenesis, the differential expression of RNASET2 between lesion tissues from vitiligo patients (n=40) and healthy tissues from donors (n=40) was detected by quantitative reverse-transcription PCR (qRT-PCR) and western blotting.

We investigate the functional implications of structural adaptations in the energy transfer performance in natural in vivo low- and high-light-adapted membrane architectures of Rhodospirillum photometricum.

Bcr-Abl-positive and negative leukemic cell lines were used to investigate the functional implications of PP1-related phosphatase activities on eIF2α phosphorylation in proteasome inhibitor-mediated ER stress and apoptosis.

To further investigate the functional implications of these differences in segment expression profiles, we also examined the differential expression of InterPro protein families.

DOI: http://dx.doi.org/10.7554/eLife.02409.026 To investigate the functional implications of filament formation, we first tested whether filament formation modulates the activity of Gln1.

To investigate the functional implications of EWS and FUS binding in representative genes, we performed depletion of FUS, EWS or both, by transfecting HEK-293 cells with siRNA.

In this study we aimed to elucidate RANK regulation at the post-transcriptional level through alternative splicing, and further investigate the functional implications of the existence of such variants on the RANK/RANKL pathway.

We set out to investigate the functional implications of the male-biased expression of the let-7-C miRNAs in the gonads and more generally its function in adult males and females.