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Randomized clinical trials (RCT) increasingly investigate combination therapies.
Building on this approach we investigate combination of an acid extraction and two stage solid phase sample extraction coupled to a MALDI-MS analysis to profile markers of response to infection in the lung.
Based on suggestive phase II evidence, recent trials frequently now investigate combination chemotherapy.
However, there is a strong preclinical rationale to investigate combination treatments of bortezomib and chemotherapy in solid tumors, including NSCLC.
While MCBT has not been used in the region, variations of this testing method have been adopted elsewhere to investigate combination therapies [ 43, 44].
Araujo et al (2005) used mathematical modelling to investigate combination therapy in which multiple nodes in a signal transduction pathway are targeted simultaneously with specific inhibitors.
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We investigate combinations of replication mechanisms and clean-up mechanisms and their impact on delay, utilization and request failure rate.
It would be interesting to investigate combinations of genes beyond these annotated pathways.
Therefore, we decided to investigate combinations of poly HPMA)–AmB with another drug attached to the polymer that has anti-leishmanial activity.
It certainly will be interesting to further investigate combinations of stimuli to determine how anemones integrate sensory input using their 'simple' nervous system.
Here, we investigated combination treatment of human colon cancer cell lines with AdDelta24-type CRAds and gene-directed enzyme prodrug therapy (GDEPT) using two different enzyme/prodrug systems, that is, thymidine kinase/ganciclovir (TK/GCV) and carboxylesterase (CE /CPT-11.
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