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The INVEST study however demonstrated equivocally the link between periodontitis and carotid artery plague [ 55].
The large INVEST study reported a direct relationship between carotid intima thickness and peridontal bacterial burden [ 212].
In the current large-sample Investigating Vascular Function Effects of Plant Sterols (INVEST) study, the primary aim was to better estimate the size and variability of the effect of a low-fat spread with added PSs on FMD.
This has been supported by results of the International Verapamil-Trandolapril (INVEST) Study conducted in a hypertensive population at high CV risk (i.e., all of whom had a history of coronary disease).
However, while in treated hypertensive patients at high CV risk an increased visit-to-visit BPV may be prognostically relevant (as shown in the INVEST study), in mildly to moderately treated hypertensive patients, BPV between visits has been shown to make little or no contribution to CV risk prediction over mean BP levels (125).
Additional data from the INVEST study (table I provides full names of trial acronyms used in this article) was also included from a publication not identified in this search.[ 29] In addition, the author was aware of and included relevant data from four studies that were presented as abstracts[ 55– 58] at scientific meetings.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com