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Therefore, calcium binding and GTP binding inversely regulate the conformational state of TG2, as well as the transamidation activity.
Ca2+ and guanine nucleotide binding inversely regulate the transamidating activity of TG2; that is, TG2 is only active as a transglutaminase when bound to Ca2+ and inactive when bound to the guanine nucleotides [3].
AGE-modified collagen can reduce the proliferation of cells [37], [38] Both ERK1/2 and AKT are known kinases integrally involved in cell proliferation [14].ecause p38 MAPK has been shown to inversely regulate the expression of these kinases in both a stress and growth environment, we investigated the role of p38 MAPK in cell proliferation.
Moreover, the abundances of c9p and c3p inversely regulate the cellular variability among the eight conditions.
Thirdly, IL-7 and TGFβ inversely regulate the production of each other [ 25, 26].
Thus, our results indicate that Fibulin-5 inversely regulate MMP-7 abundance in HCC.
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Together, these data indicate that positive regulation is more frequently performed by CepR compared to CciR, that the majority (92%) of co-regulated genes were inversely regulated by CepR and CciR and that CepR regulation can be dominant over CciR regulation.
Also, there were cases of inversely regulated genes, 14% down regulated in regions of DNA gain and 9% up regulated in regions of DNA loss.
Intriguingly, a significant number of these BACH2-regulated genes are inversely regulated by harmine, suggesting that harmine may help reverse BACH2-axis defects, for example in IBD.
Syntaxin 3A was found to be inversely regulated: It was weakly up-regulated in consequence of an increased Aβ42/Aβ40 ratio (p = 0.159, fold change 1.4), whereas it was down-regulated in consequence of a decreased one (p = 0.00268, fold change = −3.7).
Among these proteins, 43 were co-regulated in both highly pathogenic groups, while the remaining 56 were inversely regulated, i.e., up-regulated in one highly versus weakly pathogenic comparison group and down-regulated in the other comparison group.
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