Overexpression of MMP-2 is related to invasion and metastasis of several tumors [ 12], while EMs also have invasive behavior.
Hoshino, D. et al. Exosome secretion is enhanced by invadopodia and drives invasive behavior.
This indicates that low HSF2 levels permit invasive behavior and propose a role for HSF2 as a suppressor.
(Haig believes that the excessive growth is triggered by a gene called IGF2, which may act to increase the invasive behavior of trophoblasts).
BFD-22 has suppressed, indeed, the migratory and invasive behavior of B16F10 cells.
It also modifies the invasive behavior of cancer cells such as migration and adhesion.
Taken together, these results suggest that HSF2 silencing promotes EMT and plasticity of PC3 cells, which may be associated with the invasive behavior of HSF2-depleted PrCa organoids.
Seltmann, K., Fritsch, A. W., Kas, J. A. & Magin, T. M. Keratins significantly contribute to cell stiffness and impact invasive behavior.
In GSE40059, cell lines were reassigned as less invasive or invasive mostly according to their phenotype, invasive behavior and expression of the EMT marker genes77,78,79,80.
Starting around day 5, HSF2-depleted organoids already exhibited pronounced collective invasive behavior, whereas organoids with silenced HSF1 were smaller and remained round beyond day 8.
We also found that the down-regulation of Notch signaling was associated with decreased invasive behavior of GR cells.
