Exact(7)
"They are in invasion mode".
Invasive structures formed were almost exclusively multicellular and showed a chain-like invasion mode.
Camisasca et al. [2] have analyzed patient clinicopathologic data, including tumor sites, clinical and pathologic stage, histological grade, invasion mode, and perineural invasion.
Isolation of organoids from one substrate and regrowth on the reciprocal matrix indicated that these changes in invasion mode are reversible.
Potentially the same or possibly alternative secreted factors emanating from 501mel cells also augment ECM density in heterogeneous xenografts, which would too promote a protease-dependent invasion mode (Wolf et al., 2013).
These findings suggest that collective migration represents an invasion mode of high cellular and molecular order that, after loss of function of particular adhesion pathways, interconverts to single-cell dissemination and metastasis.
Similar(53)
Little is known about glioblastoma cell motility, but switches in invasion modes and adaption to specific microenvironmental cues as a consequence of treatment may maintain tumor cell resistance to therapy.
Previous studies have suggested a range of invasion modes from single cells to large clusters.
For this purpose, cancer cells must have the ability to switch from quiescent mode to proliferation mode, as well as switching between cell proliferation and cell invasion modes.
The relative importance of protease-dependent and -independent invasion modes of cancer cell invasion through interstitial barriers remains a subject of considerable debate.
In conclusion, the combination of cognition network technology and Bayesian network analysis provides an insight into morphological variables associated with transition of cancer cells between invasion modes.
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