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As a consequence of this incomplete reparative process, the disease invariably progresses and patchy areas of demyelination in which axonal damage and/or loss is a constant accompanying factor increase over time and lead to the accumulation of irreversible neurological deficits.
PD invariably progresses with time.
MM evolves and invariably progresses through therapy.
However, within 12 33 months, the disease almost invariably progresses to an androgen-independent or castrate-resistant state.
Clinically, it is characterised by dyspnoea and pulmonary arterial hypertension, which almost invariably progresses to right heart strain and cardiorespiratory arrest in hours to days.
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Things always seem to be trending in the right direction; there's invariably "progress," always carefully qualified; Washington's troops remain forever steadfast; chances are good that... you fill it in: the invasion will be successful, the occupation a smash, the surge a triumph of an unconventional sort, the latest Afghan election a positive step forward in a tough world.
The nature of the mechanistic link between high intraocular pressure and loss of retinal ganglion cells is still not fully understood and although raised IOP is clearly an important risk factor, patients with ocular hypertension do not invariably progress to clinical glaucoma and RGC degeneration, even over long-term periods [2], [4], [47] [49].
Men with CRPC who are resistant to docetaxel-based or other systemic therapy invariably progress and die from the disease.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com