Endometrial sarcomas without recognisable evidence of a definite endometrial stromal phenotype, designated as poorly differentiated endometrial sarcomas, are almost invariably high grade (Evans, 1982; Oliva et al, 2000), and termed poorly differentiated or undifferentiated uterine sarcomas.
Because these were invariably developed by analyzing all subtypes of breast cancers together, they tend to assign high risk category to almost all ER-negative cancers (which are almost always high grade), even though a substantial majority of these cancers have good prognosis [ 18, 19].
Adenocarcinomas expressing K-Ras G12D invariably exhibit uniform high-grade dysplasia throughout the gut, but this does not occur in mice expressing wild-type K-ras [31].
B-CLL is the most prevalent chronic lymphoproliferative disease and follows a typically indolent course, however 2-15% of patients [ 1- 3] transform to an invariably aggressive, chemo-resistant high-grade non-Hodgkin's lymphoma (NHL) [ 4].
Pediatric-type nodal follicular lymphoma (PTNFL) is a variant of follicular lymphoma (FL) characterized by limited-stage presentation and invariably benign behavior despite often high-grade histological appearance.
On the other hand, the presence of a high-grade glioma (if left-sided) almost invariably leads to semantic deficits that bore the hallmarks of the access syndrome.
Low-grade SIL (LSIL) (equivalent to CIN 1) and high-grade SIL (HSIL, equivalent to CIN 2 and 3) are invariably asymptomatic and can be detected through cytological examination using the Papanicolaou technique (the Pap test).
You have high-grade generators and high-grade skepticism.
China has chiefly high-grade coal reserves.
No high-grade deposits are known.
"Twenty years of high-grade, maybe.
