Pharmacological blockade of VEGF signaling to inhibit tumor angiogenesis is clinically approved but the survival benefit is limited as patients invariably acquire resistance.
Public companies which invariably acquire businesses with the intention of holding on to them and integrating them into their operations can profitably learn or borrow from this buy-to-sell approach.
Taken together, these results indicate that the amorphous calcium complexes constituting NLP invariably acquire phosphate and gradually convert to carbonate HAP, while retaining residual amounts of both amorphous carbonate and phosphate in their structure.
Cells transformed with oncogenes in vitro invariably acquire additional genetic abnormalities, either during passage in vitro or subsequently as an adaptation to growth in vivo.
8 Clinically meaningful benefit is observed in patients bearing all-RAS wild-type tumors treated with these inhibitors, even though some patients often invariably acquire secondary resistance during treatment.
Moreover, although the majority of patients do achieve a period of disease control with these drugs, resistance is invariably acquired, typically within months of starting the treatment (Motzer et al, 2007, 2009; Sternberg et al, 2010; Busch et al, 2011; Heng et al, 2012).
46 Despite this encouraging data, almost all cases invariably develop "acquired" resistance to TKIs, 40 which means the progression of the tumor that had previously responded to the treatment.
Neoplastic transformation invariably includes acquired mechanisms to evade programmed cell death.
It needs to be appreciated that over time, history has shown that public support for the banking system is unlikely to cost the tax payer huge sums; invariably it involves acquiring assets at distressed prices which can be sold later at a profit.
Use of tyrosine kinase inhibitors gefitinib, erlotinib, and crizotinib for NSCLC treatment invariably leads to acquired drug resistance [32, 33].
