DOI: http://dx.doi.org/10.7554/eLife.06132.002 The invariable development of drug resistance presents a critical challenge to the success of targeted cancer therapies (Jänne et al., 2005; O'Hare et al., 2006; Poulikakos and Rosen, 2011).
However, the invariable development of drug resistance greatly limits the effectiveness of this therapy, despite efforts to circumvent acquired genetic abnormalities, such as the recurrent T790M-EGFR gatekeeper mutation or MET amplification.
But it was only in 1305 that a settlement satisfactory to the king could be reached; even then it proved impossible to win full ratification from the Flemish townsmen, whose resistance remained an invariable factor in the latent hostility between France and England.
Since their discovery in 2006, GSCs have been advanced as the primary 'culprit' in the inherent resistance of glioblastoma to chemo/radiotherapy and the invariable maintenance of residual disease after conventional therapies (Kim et al, 2011).
While rifampicin resistance is considered a strong predictor of multidrug resistant phenotype [ 24, 25], the association is not invariable [ 26] and cannot necessarily be inferred in Kikori where no prior knowledge of drug resistance patterns exist.
These results demonstrate that the reversal of drug resistance by verapamil and other calcium antagonists in a dose-dependent fashion is not an invariable property of multidrug-resistant tumour cells.
"Like Obama!" is the invariable response.
Adverbs, prepositions, conjunctions, and interjections are invariable.
He went on to describe his "invariable" working method.
Consuelo is a Spanish abstract noun, masculine, invariable.
