Exact(2)
DOI: http://dx.doi.org/10.7554/eLife.06132.002 The invariable development of drug resistance presents a critical challenge to the success of targeted cancer therapies (Jänne et al., 2005; O'Hare et al., 2006; Poulikakos and Rosen, 2011).
However, the invariable development of drug resistance greatly limits the effectiveness of this therapy, despite efforts to circumvent acquired genetic abnormalities, such as the recurrent T790M-EGFR gatekeeper mutation or MET amplification.
Similar(58)
Furthermore, this study shows the invariable occurrence of DD/ID and the occasional (8.8%) development of hepatoblastoma, thereby showing the necessity of adequate support for DD/ID and screening of hepatoblastoma in affected patients.
63 The main advantage of genetic variants is that they remain invariable throughout life, so it is possible to determine a person's genetic risk profile before the development of an adverse cardiovascular risk factor profile, which would allow primary prevention measures to be undertaken earlier in life.
Enhance Development of Athletes Psychological Skillss.
Development of class structure.
Specific development of ideas.
Development of high fever.
Development of behavior changes.
As Poe wrote in his exposition on The Raven, "Beauty of whatever kind, in its supreme development, invariable excites the sensitive soul to tears.
As Henry Stanley put it, tsetse were the invariable sign of "an extensive habitat of game".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com