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It takes about two years to develop a knockout mouse, but the animals are invaluable for determining what a gene does by figuring out what it is that the knockout mouse cannot do.
Motion on the particle scale is difficult to measure experimentally, making computational simulations invaluable for determining the dynamics within such systems.
Mouse models of human disease are invaluable for determining the differentiation ability and functional capacity of stem cells.
This will be invaluable for determining the effects of genetic manipulations on cell behavior in vivo.
In contrast, larger epidemiology studies are invaluable for determining healthcare resource allocation and for the design and conduct of both observational and interventional clinical trials.
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The arrow diagram is an invaluable planning aid for determining how long a project will take to complete.
Population-based studies using non-nominal data from administrative databases or medical charts have been invaluable in HIV research for determining incidence, prevalence and natural history of specific HIV-related conditions [ 4- 8].
Its use as an end point for determining the adequacy of hemodynamics (blood pressure, cardiac output/cardiac index), measurement of right to left shunt, and prediction of potential hemodynamic instability makes this parameter invaluable for the knowledgeable clinician.
Owing to the practical and fundamental difficulties in detecting genetic change and drivers of such change in the wild, complementary approaches have been invaluable in determining the scope for fisheries-induced evolution and the mechanisms involved.
Although animal models, including the ERKO mice study described above, have been invaluable in determining a requirement for epithelial stromal interactions in ovarian steroid-mediated mammary morphogenesis, cell culture models have been useful to elucidate the underlying mechanisms of cell cell interactions and the cell types involved.
In some cases, histopathological evaluation has proven invaluable in determining whether underlying structural defects in the myocardium or other problems are responsible for the low blood pressure readings (Van Sligtenhorst et al., 2011).
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