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We also applied our approach on an eicosanoid production model developed for human and concluded that the model could not be invalidated using the available data despite its simplicity in the formulation of the reaction kinetics.
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Flavopiridol is a significant inhibitor of Cdk12, and if i-Cdk9 also blocks Cdk12, it would change the conclusions of the paper, and certainly invalidate using Ser2 phosphorylation as a marker for Cdk9 because Cdk12 is critical for cancer cell survival, the 'anti-cancer' effects of flavopiridol, and possibly also i-Cdk9, could have more to do with inhibition of Cdk12 than Cdk9.
Despite increased pressure on judges to support the antiterrorism effort, legal experts say it is unlikely that the court will move to invalidate use of the alien tort statute in the Unocal case.
These findings also invalidate use of ergosterol as an indicator of biomass of certain fungal taxa (e.g., Glomeromycota).
XAF-1 gene was invalidated by using XAF-1 siRNA (Santa Cruz, Heildelberg, Germany, sc-37511) according to manufacturers instructions.
Dnmt1 gene was invalidated by using siRNA approach (sc35204, Tebu-Bio France) according to manufacturer's instructions.
This showed that the model proposed for the eicosanoid production pathway could not be invalidated by using the available data.
Therefore these assumptions can be invalidated when using genes that have multiple copies, or hybridise at lower than 100% BLASTN identity match which creates natural shoulders on the primary mode [ 36].
Through a simulations study, we showed that too simple mechanistic descriptions can be invalidated by using our SPCA-based comparative approach until high amount of noise exists in the experimental data.
I don't just mean sexually objectifying us but also that objectification which reduces us to our bodies, what parts we have and don't have and uses that to invalidate us as whom we are?
They're invalidating us".
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