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This does not invalidate the conclusion that there was less C5a in the ultrafiltrate of patients anticoagulated with citrate compared to the other groups.
Even if such a mechanism did occur, the kinetics would have to be very different in the four cell lines to invalidate the conclusion that the initial level of damage is different.
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This approach did not necessarily invalidate the conclusions reached; but many valuable ideas then put forward as theories of architecture were only partial theories, in which it was taken for granted that theoretical concepts concerning construction and planning were dealt with in other texts.
It is worth mentioning that such a feedback effect does not invalidate the conclusions of this study.
This fact alone doesn't necessarily invalidate the conclusions reached, but it does ask us to dig a bit deeper.
This, however, would not invalidate the conclusions from the study.
Significant heterogeneity in terms of protein constituents would completely invalidate the conclusions.
Unpublished data may also invalidate the conclusions from meta-analyses and systematic reviews.
Skewing towards some of the responses may not invalidate the conclusions, since those responses did not exclude the others.
Inclusion of such controls would bias our results toward the null hypothesis of no difference with respect to number of risk alleles and invalidate the conclusions.
Thus. the results of Städler et al. (2009) may not invalidate the conclusions of earlier empirical studies, but they certainly encourage caution when choosing a sampling strategy.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com