But his evidence won't invalidate my point: the absence of a British equivalent of the FBI investigation will, in all likelihood, kill the story here.
To be sure, some (many) of them ended up losing their jobs when the bubble burst, but that doesn't invalidate the point: pushing sub-prime mortgages onto folks that couldn't afford them was a lucrative business, and the people who were involved in it it were simply reacting to the price signals that the market was providing to them.
that the cytotoxic effect was caused (only) by an inhibition of topoisomerase I but it might be an involved mechanism in cytotoxic procedures until further work corroborate or invalidate this point of view.
It would have been interesting to confirm (or invalidate) this point by including the capsid sequences of the DAV and permutotetraviruses in the analysis but, as explained above, we were not able to obtain convincing alignments for these virus proteins.
I'm not sure if that invalidates my point or not.
This does not invalidate the authors' points, which are well taken by this reviewer, nor is it proof of efficacy.
However that did not invalidate the Tories' point.
The latter errors are present since the calculated circles from Figure 4 will overlap, that is, a lack of distinct intersection points invalidates the centroid calculation.
The present results do not invalidate the central point of the MIM hypothesis, that the cost of misfolding is a key determinant of protein evolution.
If a bias were to be found, this would not invalidate any of the points made, but add a further important facet to the story.
Specifically, my gut feel is that you allow valid clicks as long as people click fewer than ~4-6 rapid-fire clinks in a minute, and then after that point you invalidate their clicks within a very short session period, probably around an hour or two, but you do not go back and do what everyone would expect you to do and invalidate the first ~4-6 clicks.
