"In our view, design and architecture decisions made for Virtual PC completely invalidate some basic assumptions about processes in modern Windows operating systems.
Even if this study's flaws didn't completely invalidate it (I believe they do), you would expect to see multiple additional studies that use the same basic design and perhaps actually use variable-width fonts so the findings aren't as worthless as these.
Significant heterogeneity in terms of protein constituents would completely invalidate the conclusions.
They stated that these weaknesses do not completely invalidate the study, but they may have a quantitative impact on the results.
Since any gene in our signature had to be repeated in multiple studies (i.e. in four or more for the down-regulated genes), no one study alone could completely invalidate our gene list.
There are obvious deviations from the procedures described in the study protocol, like resting time and positioning, which introduce errors if not observed, but they usually should not reach a magnitude to completely invalidate study results.
A significant problem in single-particle analysis is that an incorrect starting model can bias the result or even completely invalidate it, and there are examples in the literature of dissimilar or completely different EM structures for the same biological complex.
We did not use a Gaussian white noise since it always assumes the presence of continuous perturbations, while in real systems there are some unavoidable sparse, yet drastic, impulses that may qualitatively change the system behaviour and even completely invalidate the deterministic predictions.
And it essentially invalidates all student elections.
"It would have essentially have invalidated all swaps regulation.
Closely linked and overlapped with emotional neglect, invalidation occurs when the victim's feelings and needs are completely invalidated, usually with harmful intent.
