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While these arguments may hold some sway -- with government trust at historic lows and faux science in vogue -- they are invalid at best and at worst, represent willfully deceptive diversions.
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Given that the clinical pain conditions to which preclinical research is intended to apply are female-predominant, one could argue that preclinical research that excludes females is incomplete at best or invalid at worst" [ 33]. 2009: Studies on the relationship of the sex of patients to the influence of general anesthesia.
Therefore, in the absence of multivariable data, subgroup analysis is entirely inappropriate, rendering the aforementioned studies at best biased, at worst invalid.
Research on new intrusion detection algorithms is often at best questionable and at worst invalid, given that the results cannot be verified under realistic conditions.
Consequentially, to treat those times when we hate as invalid or to treat them as only acceptable if directed at certain others, are both problematic approaches at best and actively dangerous at worst.
"Either he's badly hurt but hell live, and at best even get thoroughly well, and at worst be a helpless cripple or an invalid or his mind impaired".
At best.
At best periodically.
tepid at best.
Silver at best.
At best, nothing.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com