However, in metastatic tumors, the adhesion molecules such as E-cadherin are usually down-regulated or mutated, and the loosened cell contact enables tumor cells to invade out from the primary niche (Cavallaro and Christofori, 2004).
The phenotype of invasive transition observed in the lumen system is analogous to the invasive phenotype observed in humans [ 43], in which cancer cells invade out from the mammary duct into the surrounding stroma.
After invading out of the primary tumor and entering the vasculature, tumor cells can in principle be transported throughout the body.
To act as a controlled release depot for T lymphocytes, the pore sizes must be small enough to prevent the random walk so the cells must actively invade out of the gel but large enough for the cells to invade through.
How long had the gang members returned to openly carrying weapons in Rocinha, where 3,000 police and armored personnel carriers in late 2011 invaded to drive out traffickers?
Shipbuilding Workshop: A Battle Pass Project (Saturday) The boats off Brooklyn are all friendly vessels today, but that wasn't true in 1776, when the British fleet invaded for what turned out to be the biggest battle of the Revolutionary War.
In 1978, Vietnam invaded Cambodia, driving out the murderous Khmer Rouge regime and installing the one that Hun Sen was to lead.
In his interview with Kelly, Bush said, "Once we invaded and took out Saddam Hussein, we didn't focus on security first, and the Iraqis in this incredibly insecure environment turned on the United States military because there was no security for themselves and their families.
"And in retrospect, once we invaded and took out Saddam Hussein, we didn't focus on security first".
In Nimmitabel in southern New South Wales, migratory flame robins invaded and eked out their territories from amid existing scarlet robin territories.
