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With Debian, all control over the packaging is with the individual package maintainers, but the scientific packages are commonly team-maintained, which facilitates mass changes like the introduction of references to catalogues from Debian in analogy to references to publications that are already offered today.
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Studies have shown that the introduction of reference price system generates significant savings during the first years of application.
Our study material allowed the analysis of the daily cost of clozapine, olanzapine and quetiapine products 39 months before and 12 months after the introduction of reference pricing.
A German study found that the introduction of reference price system reduces prices of the affected products by approximately 7% [8].
[10] On the other hand, though the initial average price reduction after the introduction of reference price system in The Netherlands was about 5%, the system also had some negative implications as the prices of several generic drugs were raised towards the maximum reimbursement level [11].
The comparability should be improved by further standardization and introduction of reference materials.
The ESI source used a separate nebulizer for the continuous introduction of reference mass compounds: 121.050873, 922.009798 (positive ion mode).
Those studies reported that the introduction of reference pricing was followed by an increase in the use of drugs priced at or below the reference level.
The ESI source used a separate nebulizer for the continuous, low-level introduction of reference mass compounds (112.985587, 1033.988109) to maintain mass axis calibration.
This clearly emphasizes the potential for obtaining fully defined de novo assemblies using third-generation sequencing technologies, which are able to resolve both local and global repeats [ 32] and avoid the introduction of reference bias.
Because ESTs are single-pass sequences and are usually error prone, the introduction of reference sequences can produce more reliable results, especially for those cDNA libraries containing low-quality sequence data.
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